There are so many questions about the
safety of this ingredient. This is mainly due to the fact that it is a form of
hydroquinone-a skin bleaching ingredient that has indicated a potential for
causing cancer, and consequently been banned in several countries.
In addition, studies have shown that high doses of hydroquinone can frequently cause ochronosis (a bluish black pigmentation of skin tissue), particularly some people of dark skin.
Arbutin appears to be less irritating than hydroquinone when used in similar concentrations. It is also reported to cause less sun sensitivity. This is most likely due to the gradual release of hydroquinone. In a word, it is regarded as a safer and gentler alternative to pure Hydroquinone.