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Product Name: Shikimate pathway
Shikimate pathway source: The Shikmic Acid is extracted from the fruit of Illicium verum Hook. f., aslocalled star aniseed. Shikimic acid, more commonly known as its anionic form shikimate, is an important biochemical metabolite in plants and microorganisms. Its name comes from the Japanese flower shikimi, from which it was first isolated.
Shikimate pathway introduction: Shikimic Acid is a key precursor of many alkaloids, aromatic amino acids, indole derivatives, and it also is widely used as a chiral building block for the synthesis of pharmaceuticals. Now, Shikimic acid serves as the starting material for Oseltamivir which is a neuraminidase inhibitor used in the treatment and prophylaxis of both influenza A and influenza B.
Appearance: white crystalline powder
Active ingredient: Shikimic acid
Shikimate pathway specifications: 90%/95%/9:1 of Shikimic acid
Test By:HPLC
Molecular formula: C7H10O5
Structural formula:
Shikimate pathway Main benefits: Star anise (Illicium verum) has been shown to possess potent antimicrobial properties. Chemical studies indicate that a major portion of this antimicrobial property is due to anethole present in the dried fruit. Studies with isolated anethole (compared with standard anethole) indicated that it is effective against bacteria, yeast and fungal strains.
Shikimic acid is a key intermediate in the biochemical pathway from phosphoenolpyruvic acid to tyrosine. It is a precursor of many alkaloids, aromatic amino acids, and indole derivatives. Shikimic acid is widely used as a chiral building block for the synthesis of pharmaceuticals. An example of end product is an antiviral drug oseltamivir, a neuraminidase inhibitor used in the treatment and prophylaxis of both influenza A and influenza B.
Shikimic acid is a high valued compound used as a key starting material for the synthesis of the neuramidase inhibitor GS4104, which was developed under the name Tamiflu for treatment of antiviral infections.
Shikimate pathway specification
ANALYSIS |
SPECIFICATION |
RESULTS |
Assay |
≥98% |
98.3% HPLC |
Specific Optical Rotation |
-165 o - -185o |
-178.8 o |
Loss on drying |
≤1% |
0.52% |
Ash content |
≤1% |
0.25% |
Part Used |
Fruits |
Conforms |
Appearance |
White fine powder |
Complies |
Shikimate pathway Microbiological Tests |
||
Salmonella |
Negative |
Negative |
Total Yeast & Mold |
≤100cfu/g |
23 cfu/g |
Total Plate Count |
≤1000cfu/g |
126cfu/g |
E.Coli |
Negative |
Negative |
Staphylococcus |
Negative |
Negative |
Shikimate pathwayHeavy metals |
≤20ppm |
Conforms |
Fe |
<2ppm |
Conforms |
Arsenic |
<2ppm |
Conforms |