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Product Name: Shikimate pathway

Shikimate pathway source: The Shikmic Acid is extracted from the fruit of  Illicium verum Hook. f., aslocalled star aniseed. Shikimic acid, more commonly known as its anionic form shikimate, is an important biochemical metabolite in plants and microorganisms. Its name comes from the Japanese flower shikimi, from which it was first isolated.

Shikimate pathway introduction: Shikimic Acid is a key precursor of many alkaloids, aromatic amino acids, indole derivatives, and it also is widely used as a chiral building block for the synthesis of pharmaceuticals. Now, Shikimic acid serves as the starting material for Oseltamivir which is a neuraminidase inhibitor used in the treatment and prophylaxis of both influenza A and influenza B.

Appearance: white crystalline powder

Active ingredient: Shikimic acid

Shikimate pathway specifications: 90%/95%/9:1 of Shikimic acid

Test By:HPLC

Molecular formula: C7H10O5

Structural formula: 

Shikimate pathway Main benefits: Star anise (Illicium verum) has been shown to possess potent antimicrobial properties. Chemical studies indicate that a major portion of this antimicrobial property is due to anethole present in the dried fruit. Studies with isolated anethole (compared with standard anethole) indicated that it is effective against bacteria, yeast and fungal strains.

Shikimic acid is a key intermediate in the biochemical pathway from phosphoenolpyruvic acid to tyrosine. It is a precursor of many alkaloids, aromatic amino acids, and indole derivatives. Shikimic acid is widely used as a chiral building block for the synthesis of pharmaceuticals. An example of end product is an antiviral drug oseltamivir, a neuraminidase inhibitor used in the treatment and prophylaxis of both influenza A and influenza B.

Shikimic acid is a high valued compound used as a key starting material for the synthesis of the neuramidase inhibitor GS4104, which was developed under the name Tamiflu for treatment of antiviral infections.

Shikimate pathway specification



ANALYSIS

SPECIFICATION

RESULTS

Assay

98%

98.3%   HPLC

Specific Optical Rotation

-165 o - -185o

-178.8 o

Loss on drying

1%

0.52%

Ash content

1%

0.25%

Part Used

Fruits

Conforms

Appearance

White fine powder

Complies

Shikimate pathway Microbiological Tests

Salmonella

Negative

Negative

Total Yeast & Mold

≤100cfu/g

23 cfu/g

Total Plate Count

≤1000cfu/g

126cfu/g

E.Coli

Negative

Negative

Staphylococcus

Negative

Negative

Shikimate pathwayHeavy metals

20ppm

Conforms

Fe

<2ppm

Conforms

Arsenic

<2ppm

Conforms

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